• • Reduce fatigue symptoms from thyroid disease
  • Regulate circadian adrenal function
  • Stabilize energy levels
  • Raise exercise capacity
  • Improve depth of sleep

The nutraceuticals with the greatest amount of evidence include:

• • L-Citrulline
  • Eleutherococcus
  • Cordyceps

These are combined with other synergistic ingredients in a blend called Adrenal. It is made to improve energy levels among those with thyroid disease or adrenal dysfunction. You can learn more about it here. 

Following are some details about how these ingredients can help boost energy. 

L-Citrulline 

L-Citrulline might be one of the coolest things most people haven’t heard of. Consider it a secret weapon found in watermelon.

(Citrulline malate) is an amino acid that has been shown to improve exercise capacity of males and females. It is converted by the kidneys into L-arginine and nitric oxide. 

When nitric oxide levels increase, blood flow to muscles improves, raising physical energy and recovery from activity.

In older adults, supplementing with L-citrulline was shown to improve physical performance and the breakdown from fat more than high-intensity interval training (HIIT) alone.¹⁸

In a study on L-Citrulline and female strength, female athletes took L-Citrulline or placebo on two separate occasions. Those supplementing with L-Citrulline showed more upper body and lower body strength without increased exertion as measured by heart rate. They were able to generate more energy without pushing themselves harder¹⁹

Eleutherococcus

AKA Siberian Ginseng, Eleutherococcus senticosusis the root of an Asian plant with a long history of use as an adaptogen and energy tonic. It is known to act as an antioxidant, an immune tonic, and a blood sugar regulator.

In a review of multiple studies, Eleutherococcus has been shown to regulate the output of adrenal hormones in chronic stress conditions and improve the response of the parasympathetic system. It has also been shown to improve energy metabolism and biological responses to hypoxia.¹⁶

In a recent placebo-controlled blinded human clinical trial, 87 participants were selected to evaluate the effects of Eleutherococcus on chronic stress. Compared to those on placebo, those receiving Eleutherococcus showed improvements in surveys regarding symptoms of fatigue and depression.¹⁷

Cordyceps

OK, this story starts out weird. This is a fungus that grows in the silkworm larva cocoons! You have to wonder how anyone thought it was a good idea to eat it. 

Cordyceps Sinensis is a fungus related to dietary mushrooms. It has been used as an energy tonic throughout Asia since the earliest recorded medical treaties. 

Cordyceps has been proven to improve energy by lowering thyroid antibodies, reducing inflammation, increasing endogenous antioxidant capacity, increasing glycogen storage, and improving immune regulation.¹

In a study of energy levels in adults aged 50-75, participants consumed cordyceps or a placebo for 12 weeks. Exercise performance measured by metabolic threshold increased by over 10% and by ventilatory threshold over 8% in those taking cordyceps. They were able to generate more energy than before due to the effects of cordyceps.²

These are combined with other synergistic ingredients in a blend called Adrenal. It is made to improve energy levels among those with thyroid disease or adrenal dysfunction. You can learn more about it here. 

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¹ He T, Zhao R, Lu Y, et al. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evid Based Complement Alternat Med. 2016;2016:1360386. doi:10.1155/2016/1360386

¹⁶ Panossian, A., & Wikman, G. (2009). Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular Mechanisms Related to their Stress-Protective Activity. Current Clinical Pharmacology, 4(3), 198–219. doi:10.2174/157488409789375311d

¹⁷ Jacquet A, Grolleau A, Jove J, Lassalle R, Moore N. Burnout: evaluation of the efficacy and tolerability of TARGET 1® for professional fatigue syndrome (burnout). J Int Med Res. 2015 Feb;43(1):54-66. doi: 10.1177/0300060514558324. Epub 2014 Dec 23. PMID: 25537278.

¹⁸  F B, L P C, V M, M D, G HB, G G, P G, P N, M AL. High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. Exp Gerontol. 2020 Oct 15;140:111036. doi: 10.1016/j.exger.2020.111036. Epub 2020 Jul 25. PMID: 32721549.

¹⁹ Glenn JM, Gray M, Wethington LN, Stone MS, Stewart RW Jr, Moyen NE. Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Eur J Nutr. 2017 Mar;56(2):775-784. doi: 10.1007/s00394-015-1124-6. Epub 2015 Dec 11. PMID: 26658899.